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Reactivity of N‐benzyl‐3‐nitrophthalimide: A facile access to isoindolo[1,2‐d][3,5]benzothiazocine derivatives

Identifieur interne : 001094 ( France/Analysis ); précédent : 001093; suivant : 001095

Reactivity of N‐benzyl‐3‐nitrophthalimide: A facile access to isoindolo[1,2‐d][3,5]benzothiazocine derivatives

Auteurs : Abderrahim Chihab-Eddine [Maroc] ; Abderrahim Jilale [Maroc] ; Adam Daïch [France] ; Bernard Decroix [France]

Source :

RBID : ISTEX:04A5612D5EC7F1BBD0B6D446161FD0E8AEE5F0DB

Abstract

A functionalized isoindolo[1,2‐d][3,5]benzothiazocine 2B has been synthesized in three steps from the nitro‐imide derivative 5. The key step of this sequence was the cyclization of the thioglycolic acid derivative 9 under acidic conditions. An evaluation of the reactivity of the imide 5 and the corresponding N‐acyliminium ion toward borohydride reduction, organometallic addition, Meyer‐Schuster rearrangement and intermolecular alkoxylation and thioalkoxylation reactions was reported.

Url:
DOI: 10.1002/jhet.5570370622


Affiliations:


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ISTEX:04A5612D5EC7F1BBD0B6D446161FD0E8AEE5F0DB

Le document en format XML

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